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SDMC


Domestic Prevention Working Group

DPWG Quick Links

Research Agenda

Domestic Studies

DPWG Contacts

The HPTN Domestic Prevention agenda seeks to support research in vulnerable persons at especially high risk.  We highlight interventions that can have a measurable impact on U.S. incidence rates, should interventions prove efficacious and be implemented successfully. Increasing HIV incidence rates in some populations suggest new urgency to undertake U.S.-specific prevention research, as well as to ensure the inclusion of U.S. populations in new research initiated in international settings. Renewing HIV prevention in the U.S. requires a fresh look at the characteristics of the epidemic, creative recruitment strategies for populations-at-risk, overcoming institutional barriers that limit the range of feasible interventions for particular subpopulations (e.g., incarcerated and paroled individuals), enhancing scale-up and access to what we already know works, and the development and use of innovative intervention tools and strategies.

The HPTN and its Domestic Prevention Working Group (DPWG) address these unanswered questions in four ways:

  • monitoring of new scientific findings;

  • ongoing assessment and expansion of its domestic prevention research portfolio;

  • development of relevant bridging studies; and

  • enhanced collaboration with other research groups and with public health agencies.

Research Agenda

Over the past decade, the estimated annual number of new HIV infections in the U.S. has remained stable with no evidence of a decrease. In view of this fact, the DPWG embarked on an analysis of the current domestic HIV/AIDS epidemic with a focus on seeking a deeper understanding of characteristics of this epidemic. In addition, the DPWG also reviewed non-vaccine, non-microbicide research in the context of the domestic setting and identified key areas of importance for future research endeavors. This review is included in its report “Responding to an Evolving US Epidemic: An HIV Prevention Research Agenda" that represents a call to action for researchers, funders and communities to come together to confront the continued threat of HIV in the U.S.

Leading investigators of the HPTN Domestic Research agenda -- Wafaa El-Sadr, Sally Hodder, Ken Mayer, and Sten Vermund -- presented their research portfolio to the NIAID Strategic Working Group Meeting on May 19, 2008.  View the team's presentations here.

Domestic HPTN Studies

 

Protocol Number Protocol Title Status

HPTN 061

10666

Feasibility of a community-level, multi-component intervention for Black MSM in preparation for a Phase IIB community-level randomized trial to test the efficacy of the intervention in reducing HIV incidence among Black MSM In Development

HPTN 062

10667

An Individual-Level Prevention Intervention for Individuals with Acute HIV Infection In Development

HPTN 064

10705

The Women’s HIV SeroIncidence Study (ISIS) In Development

 

DPWG Contacts

 

Working Group Chair: Wafaa El-Sadr, Columbia University, Mailman School of Public Health
CORE Working Group Manager: Sam Griffith and Danielle Haley, Family Health International

      

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This page was last updated: May 20, 2008