|
HIV
Prevention Trials Units
Network Leadership Scientific
Management
Network
Committees
CORE
Network Lab
SDMC
|
|
Domestic Prevention Working
Group
The HPTN Domestic Prevention
agenda seeks to support research in vulnerable persons at especially
high risk. We highlight interventions that can have a measurable impact on U.S.
incidence rates, should interventions prove efficacious and be
implemented successfully. Increasing HIV incidence rates in some populations suggest new
urgency to undertake U.S.-specific prevention research, as well as
to ensure the inclusion of U.S. populations in new research initiated in international settings. Renewing HIV prevention in the
U.S. requires a fresh look at the characteristics of the epidemic,
creative recruitment strategies for populations-at-risk, overcoming
institutional barriers that limit the range of feasible interventions
for particular subpopulations (e.g., incarcerated and paroled
individuals), enhancing scale-up and access to what we already know
works, and the development and use of innovative intervention tools and
strategies.
The HPTN and its Domestic
Prevention Working Group (DPWG) address these unanswered questions
in four ways:
-
monitoring of new scientific findings;
-
ongoing assessment and
expansion of its domestic prevention research portfolio;
-
development of
relevant bridging studies; and
-
enhanced collaboration with other
research groups and with public health agencies.
Research Agenda
Over the past decade, the
estimated annual number of new HIV infections in the U.S. has remained
stable with no evidence of a decrease. In view of this fact, the DPWG embarked on an
analysis of the current domestic HIV/AIDS epidemic with a focus on
seeking a deeper understanding of characteristics of this epidemic. In
addition, the DPWG also reviewed non-vaccine, non-microbicide research
in the context of the domestic setting and identified key areas of
importance for future research endeavors. This review is included in its
report
“Responding to an Evolving US Epidemic: An HIV Prevention Research
Agenda" that represents a call to action for researchers, funders
and communities to come together to confront the continued threat of HIV
in the U.S.
Leading investigators of the
HPTN Domestic Research agenda --
Wafaa El-Sadr,
Sally Hodder,
Ken Mayer, and
Sten Vermund -- presented their research portfolio to the NIAID
Strategic Working Group Meeting on May 19, 2008. View the team's
presentations
here.
Domestic HPTN Studies
|
Protocol Number |
Protocol
Title |
Status |
|
HPTN 061
10666 |
Feasibility of a community-level, multi-component intervention for Black MSM in preparation for a Phase IIB community-level randomized trial to test the efficacy of the intervention in reducing HIV incidence among Black MSM |
In Development |
|
HPTN 062
10667 |
An Individual-Level Prevention Intervention for Individuals with Acute HIV Infection |
In Development |
|
HPTN 064
10705 |
The Women’s HIV SeroIncidence Study (ISIS) |
In Development |
DPWG
Contacts
Working Group Chair:
Wafaa El-Sadr, Columbia University, Mailman School of Public Health
CORE Working Group Manager:
Sam Griffith and
Danielle Haley, Family Health International |
|
