Domestic Prevention Working Group
The HPTN Domestic Prevention agenda seeks to support research in vulnerable persons at especially high risk. We highlight interventions that can have a measurable impact on U.S. incidence rates, should interventions prove efficacious and be implemented successfully. Increasing HIV incidence rates in some populations suggest new urgency to undertake U.S.-specific prevention research, as well as to ensure the inclusion of U.S. populations in new research initiated in international settings. Renewing HIV prevention in the U.S. requires a fresh look at the characteristics of the epidemic, creative recruitment strategies for populations-at-risk, overcoming institutional barriers that limit the range of feasible interventions for particular subpopulations (e.g., incarcerated and paroled individuals), enhancing scale-up and access to what we already know works, and the development and use of innovative intervention tools and strategies.
The HPTN and its Domestic Prevention Working Group (DPWG) address these unanswered questions in four ways:
- monitoring of new scientific findings;
- ongoing assessment and expansion of its domestic prevention research portfolio;
- development of relevant bridging studies; and
- enhanced collaboration with other research groups and with public health agencies.
Domestic Research Agenda
Over the past decade, the estimated annual number of new HIV infections in the U.S. has remained stable with no evidence of a decrease. The data also show that Black and Latino men who have sex with men (MSM) and Black and Latina women are disproportionately impacted by HIV, but continue to be underrepresented in HIV prevention research. In view of these facts, the DPWG embarked on an analysis of the current domestic HIV/AIDS epidemic with a focus on seeking a deeper understanding of characteristics of this epidemic. In addition, the DPWG also reviewed non-vaccine, non-microbicide research in the context of the domestic setting and identified key areas of importance for future research endeavors. This review is included in its report “Responding to an Evolving US Epidemic: An HIV Prevention Research Agenda" that represents a call to action for researchers, funders and communities to come together to confront the continued threat of HIV in the U.S. One critical component of that work is our effort to increase engagement in HIV prevention research among Black and Latino community members. Summaries of those efforts will be linked here as they become available. Please also find more frequent information updates on Twitter and Facebook by searching US_HIV_Prev.
Leading investigators of the HPTN Domestic Research agenda -- Wafaa El-Sadr, Sally Hodder, Ken Mayer, and Sten Vermund -- presented their research portfolio to the NIAID Strategic Working Group Meeting on May 19, 2008. View the team's presentations here. A list of the domestic research agenda protocols are listed under the heading Domestic HPTN Studies section below.
Domestic HPTN Studies
| Protocol Number | Protocol Title | Status |
|---|---|---|
|
10666 |
Feasibility of a community-level, multi-component intervention for Black MSM in preparation for a Phase IIB community-level randomized trial to test the efficacy of the intervention in reducing HIV incidence among Black MSM | Enrolling |
|
10667 |
Feasibility and Acceptability Study of an Individual-Level Behavioral Intervention for Individuals with Acute and Early HIV-Infection | Open to Accrual |
|
10705 |
The Women’s HIV SeroIncidence Study (ISIS) | Enrolling |
|
HPTN 065 10841 |
TLC-Plus: A Study to Evaluate the Feasibility of an Enhanced Test, Link to Care Plus Treat Approach for HIV Prevention in the United States | Pending |
DPWG Contacts
Working Group Chair: Wafaa El-Sadr, Columbia University, Mailman School of Public Health
CORE Working Group Managers: Sam Griffith and Danielle Haley, Family Health International
Community Engagement Officer (for general DPWG information: Georgette King, Family Health International
Follow updates from the HPTN domestic research team on Twitter at http://twitter.com/US_HIV_Prev and fan US_HIV_Prev on Facebook.
