HIV Prevention Trials Network

Network Groups

Domestic Prevention Working Group
 

The HPTN Domestic Prevention agenda seeks to support research in vulnerable persons at especially high risk.  We highlight interventions that can have a measurable impact on U.S. incidence rates, should interventions prove efficacious and be implemented successfully. Increasing HIV incidence rates in some populations suggest new urgency to undertake U.S.-specific prevention research, as well as to ensure the inclusion of U.S. populations in new research initiated in international settings. Renewing HIV prevention in the U.S. requires a fresh look at the characteristics of the epidemic, creative recruitment strategies for populations-at-risk, overcoming institutional barriers that limit the range of feasible interventions for particular subpopulations (e.g., incarcerated and paroled individuals), enhancing scale-up and access to what we already know works, and the development and use of innovative intervention tools and strategies.

 

The HPTN and its Domestic Prevention Working Group (DPWG) address these unanswered questions in four ways:

  • monitoring of new scientific findings;

  • ongoing assessment and expansion of its domestic prevention research portfolio;

  • development of relevant bridging studies; and

  • enhanced collaboration with other research groups and with public health agencies.

Domestic Research Agenda

Over the past decade, the estimated annual number of new HIV infections in the U.S. has remained stable with no evidence of a decrease.  The data also show that Black and Latino men who have sex with men (MSM) and Black and Latina women are disproportionately impacted by HIV, but continue to be underrepresented in HIV prevention research. In view of these facts, the DPWG embarked on an analysis of the current domestic HIV/AIDS epidemic with a focus on seeking a deeper understanding of characteristics of this epidemic. In addition, the DPWG also reviewed non-vaccine, non-microbicide research in the context of the domestic setting and identified key areas of importance for future research endeavors. This review is included in its report “Responding to an Evolving US Epidemic: An HIV Prevention Research Agenda" that represents a call to action for researchers, funders and communities to come together to confront the continued threat of HIV in the U.S. One critical component of that work is our effort to increase engagement in HIV prevention research among Black and Latino community members. Summaries of those efforts will be linked here as they become available.

 

Presentations, Meetings and Workshops

 

HPTN 066 Presentation by Craig Hendrix (June 2010)

 

June 2010 Meeting Minutes

 

HPTN 061 Presentation by Beryl Koblin (May 2010)

 

March 2010 Meeting Materials

 

DPWG Agenda Presentation (Mar 2010)

 

 

HPTN Scholars Awards

Six awards have been made through this new programs.  Read more.

 

Domestic HPTN Studies

Protocol Number Protocol Title Status

HPTN 061

10666

Feasibility of a community-level, multi-component intervention for Black MSM in preparation for a Phase IIB community-level randomized trial to test the efficacy of the intervention in reducing HIV incidence among Black MSM Closed to Follow Up

HPTN 062

10667

Feasibility and Acceptability Study of an Individual-Level Behavioral Intervention for Individuals with Acute and Early HIV-Infection Closed to Accrual

HPTN 064

10705

The Women’s HIV SeroIncidence Study (ISIS) Closed to Follow Up

HPTN 065

11685

TLC-Plus: A Study to Evaluate the Feasibility of an Enhanced Test, Link to Care, Plus Treat Approach for HIV Prevention in the United States Enrolling

   

DPWG Resources:

 

HPTN 061 Recruitment web site:  www.blackmenstandtogether.org

 

 

Follow updates from the HPTN domestic research team on Twitter at http://twitter.com/US_HIV_Prev
Fan USHIVPrev on Facebook - http://facebook.com/USHIVPrev

 

NEW!  TLC-Plus FAQs  

 

DPWG Contacts

Working Group Chair: Wafaa El-Sadr, Columbia University, Mailman School of Public Health

CORE Working Group Managers: Sam Griffith and Danielle Haley, Family Health International

Community Engagement Officer  Georgette King, Family Health International - for general information about HPTN's domestic agenda.

 

 

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