Domestic Prevention Working Group

The HPTN Domestic Prevention agenda seeks to support research in vulnerable persons at especially high risk. We highlight interventions that can have a measurable impact on U.S. incidence rates, should interventions prove efficacious and be implemented successfully. Increasing HIV incidence rates in some populations suggest new urgency to undertake U.S.-specific prevention research, as well as to ensure the inclusion of U.S. populations in new research initiated in international settings. Renewing HIV prevention in the U.S. requires a fresh look at the characteristics of the epidemic, creative recruitment strategies for populations-at-risk, overcoming institutional barriers that limit the range of feasible interventions for particular subpopulations (e.g., incarcerated and paroled individuals), enhancing scale-up and access to what we already know works, and the development and use of innovative intervention tools and strategies.

The HPTN and its Domestic Prevention Working Group (DPWG) address these unanswered questions in four ways:

monitoring of new scientific findings;
ongoing assessment and expansion of its domestic prevention research portfolio;
development of relevant bridging studies; and
enhanced collaboration with other research groups and with public health agencies.

Domestic Research Agenda

Over the past decade, the estimated annual number of new HIV infections in the U.S. has remained stable with no evidence of a decrease. The data also show that Black and Latino men who have sex with men (MSM) and Black and Latina women are disproportionately impacted by HIV, but continue to be underrepresented in HIV prevention research. In view of these facts, the DPWG embarked on an analysis of the current domestic HIV/AIDS epidemic with a focus on seeking a deeper understanding of characteristics of this epidemic. In addition, the DPWG also reviewed non-vaccine, non-microbicide research in the context of the domestic setting and identified key areas of importance for future research endeavors. This review is included in its report “Responding to an Evolving US Epidemic: An HIV Prevention Research Agenda" that represents a call to action for researchers, funders and communities to come together to confront the continued threat of HIV in the U.S. One critical component of that work is our effort to increase engagement in HIV prevention research among Black and Latino community members. Summaries of those efforts will be linked here as they become available.

Presentations, Meetings and Workshops

HPTN 066 Presentation by Craig Hendrix (June 2010)

June 2010 Meeting Minutes

HPTN 061 Presentation by Beryl Koblin (May 2010)

March 2010 Meeting Materials

DPWG Agenda Presentation (Mar 2010)

HPTN Scholars Awards

Six awards have been made through this new programs. Read more.

Domestic HPTN Studies

Protocol Number	Protocol Title	Status
HPTN 061 10666	Feasibility of a community-level, multi-component intervention for Black MSM in preparation for a Phase IIB community-level randomized trial to test the efficacy of the intervention in reducing HIV incidence among Black MSM	Closed to Follow Up
HPTN 062 10667	Feasibility and Acceptability Study of an Individual-Level Behavioral Intervention for Individuals with Acute and Early HIV-Infection	Closed to Accrual
HPTN 064 10705	The Women’s HIV SeroIncidence Study (ISIS)	Closed to Follow Up
HPTN 065 11685	TLC-Plus: A Study to Evaluate the Feasibility of an Enhanced Test, Link to Care, Plus Treat Approach for HIV Prevention in the United States	Enrolling

DPWG Resources:

HPTN 061 Recruitment web site: www.blackmenstandtogether.org

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