Substance Use Research
Overview
While declines in HIV/AIDS incidence and mortality have occurred in several areas of the world, HIV transmission among non-injection and injecting drug users (IDUs) remains an urgent and expanding global health problem. There is significant epidemiologic relevance to prevention efforts that focus on IDUs. The majority of new HIV infections in Eastern Europe, Russia, and South East Asia are attributable to injection-related risk behaviors. In the Unites States, an estimated 16% of people living with HIV were infected through injection drug use. While the mechanisms of HIV transmission among IDUs are reasonably clear, ongoing research is needed to develop and tailor effective HIV prevention interventions.
The HPTN’s research focus in this area includes reducing HIV transmission among injection and non-injection substance users (e.g., alcohol, crack cocaine, and other non-injection drugs), developing and refining primary and secondary prevention interventions for HIV-infected drug users, and evaluating interventions designed to overcome structural and community level barriers to accepting and implementing effective HIV prevention strategies.
HPTN Substance Use Studies
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A Phase III randomized controlled trial to evaluate the efficacy of drug treatment and death in prevention of HIV infection and death among opiate dependent injectors |
(Closed to Follow Up) | |
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A Phase III Randomized Study to Evaluate the Efficacy of a Network-oriented Peer Educator Intervention for the Prevention of HIV Transmission Among Injection Drug Users And Their Network Members |
(Concluded) | |
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HIV Prevention Preparedness Study |
(Concluded) |
