HPTN Research Studies

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Study Phase Definitions

HPTN Studies

HPTN research studies are developed by protocol teams that include CTU investigators and recognized experts in HIV prevention. As study protocols are developed, they undergo a rigorous intra- and extra-network review process that ensures compliance with current ethical guidelines and regulatory procedures.

To view detailed information about studies, including performance sites and enrollment figures, select a protocol number from the tables below. Each Study Protocol is available once version 1.0 is approved and distributed to the performance sites. The CORE Protocol Contact can provide additional information and materials.

Ongoing Studies and Studies in Development

Protocol Number	Protocol Title	Status
HPTN 027 10141	A Phase I Study to Evaluate the Safety and Immunogenicity of ALVAC-HIV vCP1521 in Infants Born to HIV-1 Infected Women in Uganda	Closed to Accrual
HPTN 035 10065	Phase II/IIb Safety and Effectiveness Study of the Vaginal Microbicides BufferGel and 0.5% PRO2000/5 Gel (P) for the Prevention of HIV Infection in Women	Closed to Accrual
HPTN 039-01 10067	Ancillary Study: Prospective Cohort Study of HPTN 039 Seroconverters: The Effect of HSV-2 Suppression on HIV-1 Viral Set Point	Closed to Accrual
HPTN 043	A Phase III Randomized Controlled Trial of Community Mobilization, Mobile Testing, Same-Day Results, and Post-Test Support for HIV in Sub-Saharan Africa and Thailand	Enrolling
HPTN 046 10142	Phase III Trial to Determine the Efficacy and Safety of an Extended Regimen of Nevirapine in Infants Born to HIV Infected Women to Prevent Vertical HIV Transmission During Breastfeeding	Enrolling
HPTN 052 10068	A Randomized Trial to Evaluate the Effectiveness of Antiretroviral Therapy Plus HIV Primary Care versus HIV Primary Care Alone to Prevent the Sexual Transmission of HIV-1 in Serodiscordant Couples	Enrolling
HPTN 057 10143	A Phase I Open Label Trial of the Safety and Pharmacokinetics of Tenofovir Disoproxil Fumarate in HIV-1 Infected Pregnant Women and their Infants	Enrolling
HPTN 058 10144	A Phase III randomized controlled trial to evaluate the efficacy of drug treatment in prevention of HIV infection among opiate dependent injectors	Enrolling
HPTN 061 10666	Feasibility of a community-level, multi-component intervention for Black MSM in preparation for a Phase IIB community-level randomized trial to test the efficacy of the intervention in reducing HIV incidence among Black MSM	In Development
HPTN 062 10667	An Individual-Level Prevention Intervention for Individuals with Acute HIV Infection	In Development
HPTN 063 10668	Preparing for international prevention trials involving HIV-infected individuals in care settings	In Development
HPTN 064 10705	The Women’s HIV SeroIncidence Study (ISIS)	In Development

Completed Studies

Protocol Number	Protocol Title	Status
HIVNET 012	A Phase IIB Trial to Determine the Efficacy of Oral AZT and the Efficacy of Oral Nevirapine for the Prevention of Vertical Transmission of HIV-1 Infection in Pregnant Ugandan Women and Their Neonates	Closed to Follow Up
HIVNET 015	EXPLORE: A Randomized Clinical Trial of the Efficacy of a Behavioral Intervention to Prevent Acquisition of HIV among Men who have Sex with Men (MSM)	Concluded
HIVNET 016A	Condom Promotion and Counseling Study	Concluded
HIVNET 024	Phase III Trial of Antibiotics to Reduce Chorioamnionitis-Related Perinatal HIV Transmission	Participants Off Study & Primary Analysis Complete
HPTN 032	Male Tolerance Study of BufferGel and PRO 2000/5 Gel (P)	Concluded
HPTN 033	HIV Prevention Preparedness Study	Closed to Follow Up
HPTN 034 10199	HIV Incidence and Participant Retention Protocol, Pune, India	Participants Off Study & Primary Analysis Complete
HPTN 036	HIV Prevalence, Incidence, and HSV-2 Prevalence Among High-Risk MSM in Perú	Concluded
HPTN 037 10125	A Phase III Randomized Study to Evaluate the Efficacy of a Network-oriented Peer Educator Intervention for the Prevention of HIV Transmission Among Injection Drug Users And Their Network Members	Closed to Follow Up
HPTN 039 10066	A Phase III, randomized, double-blind, placebo-controlled trial of acyclovir for the reduction of HIV acquisition among high risk HSV-2 seropositive, HIV-seronegative individuals	Participants Off Study & Primary Analysis Complete
HPTN 047	A Phase I Safety and Acceptability Study of the Investigational Vaginal Microbicide PRO 2000/5 Gel (P)	Concluded
HPTN 049	Phase I Safety and Acceptability Study of the Vaginal Microbicide 6% Cellulose Sulfate Gel Among HIV-Infected Women	Concluded
HPTN 050	Phase I Safety and Acceptability Study of the Vaginal Microbicide Agent PMPA Gel	Concluded
HPTN 055	HIV Prevention Preparedness Study	Concluded
HPTN 056	Characterization of Baseline Mucosal Indices of Injury and Inflammation in Men for Use in Rectal Microbicide Trials	Participants Off Study & Primary Analysis Complete
HPTN 059 10145	Phase II Expanded Safety and Acceptability Study of the Vaginal Microbicide 1% Tenofovir Gel	Closed to Follow Up

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This page was last updated: June 07, 2007