HPTN 052

A Randomized Trial to Evaluate the Effectiveness of Antiretroviral Therapy Plus HIV Primary Care versus HIV Primary Care Alone to Prevent the Sexual Transmission of
HIV-1 in Serodiscordant Couples

Study Oversight

Several committees provide oversight and review of HPTN 052.  This website provides information regarding the membership and activities of these committees.

Clinical Management Committee (CMC)

The CMC is responsible for answering clinically-related questions. Questions to this committee can include, but are not limited to:

    • Questions about inclusion and exclusion criteria for particular participants
    • Questions about protocol interpretation
    • Questions about ART management (e.g., regimen change or toxicity management)
    • Questions about primary HIV care
    • Questions about the clinical management of co-morbidities
    • Questions about the prophylaxis and treatment of OIs
    • Questions about AE management
    • Questions about grading and reporting AEs and EAEs

    Clinically-related questions may be submitted to the CMC by sending email to 052CMC@HPTN.org

    CMC Roster

    CMC Schedule (Apr 2013 - Nov 2013) (Effective 1 Apr 2013)

    CMC Questions and Answers

Protocol Safety Review Team (PSRT)

The PSRT conducts regular reviews of standardized study safety data reports and relays any identified safety concerns to the DAIDS Vaccine and Prevention Data and Safety Monitory Board.