Study Oversight

Several committees provide oversight and review of HPTN 052.  This website provides information regarding the membership and activities of these committees.

• Clinical Management Committee (CMC)
  • The CMC is responsible for answering clinically-related questions. Questions to this committee can include, but are not limited to:
    • Questions about inclusion and exclusion criteria for particular participants
    • Questions about protocol interpretation
    • Questions about ART management (e.g., regimen change or toxicity management)
    • Questions about primary HIV care
    • Questions about the clinical management of co-morbidities
    • Questions about the prophylaxis and treatment of OIs
    • Questions about AE management
    • Questions about grading and reporting AEs and EAEs
  • Clinically-related questions may be submitted to the CMC by sending email to 052CMC@HPTN.org
  • CMC Roster
  • CMC Schedule (Feb 2008 - Sep 2008) (17 Mar 2008)
  • CMC Schedule (Sep 2008 - Apr 2009) (Effective September 14, 2008)
  • CMC Questions and Answers

• Protocol Safety Review Team (PSRT)
  • PSRT Roster
• Safety Monitoring Committee (SMC)
  • SMC Roster
  • SMC Reports
    • SMC Open Report 5 Apr 2007
    • SMC Report 26 May 2006
    • SMC Report 30 Sep 2005
  • SMC Recommendations/Minutes
    • SMC Review Minutes 26 May 2006
    • SMC Review Recommendations 26 May 2006
    • SMC Review Summary 30 Sep 2005
• Data Safety Monitoring Board (DSMB)
  • DSMB Roster
  • DSMB Open Reports
    • DSMB Open Report 12 Jul 2006
    • DSMB Open Report 12 Jul 2006 Appendix
    • DSMB Open Report 08 Nov 2005
    • DSMB Open Report 08 Nov 2005 Appendix
  • DSMB Recommendations/Minutes
    • DSMB Review Recommendations 2-3 May 2007