HPTN Studies by Research Area
Anti-Retroviral Therapy
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A Randomized Trial to Evaluate the Effectiveness of Antiretroviral Therapy Plus HIV Primary Care versus HIV Primary Care Alone to Prevent the Sexual Transmission of HIV-1 in Serodiscordant Couples |
(Closed to Accrual) | |
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TLC-Plus: A Study to Evaluate the Feasibility of an Enhanced Test, Link to Care, Plus Treat Approach for HIV Prevention in the United States |
(Enrolling) | |
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Dose-Proportionality and Intra-Individual Variability of Intracellular Tenofovir Diphosphate and Emtricitabine Triphosphate in Healthy Volunteers |
(Re-Opened) | |
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Phase II Randomized, Double-Blind, Study of Safety and Tolerability of Maraviroc, Maraviroc + Emtricitabine, Maraviroc + Tenofovir or Tenofovir + Emtricitabine for PreExposure Prophylaxis to Prevent HIV Transmission in At-Risk Men Who Have Sex with Men |
(Enrolling) | |
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International Test and Linkage to Care and Treatment |
(Withdrawn) | |
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Population Effects of Antiretroviral Therapy to Reduce HIV Transmission (PopART): A cluster-randomized trial of the impact of a combination prevention package on population-level HIV incidence in Zambia and South Africa |
(Pending) | |
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Pre-Exposure Prophylaxis (PrEP) Initiation and Adherence among Black Men who have Sex with Men (BMSM) in Three U.S. Cities |
(Pending) | |
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Treatment as prevention for injection drug users: A pilot study for a network-based randomized HIV prevention trial |
(In Development) |
Behavioral
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EXPLORE: A Randomized Clinical Trial of the Efficacy of a Behavioral Intervention to Prevent Acquisition of HIV among Men who have Sex with Men (MSM) |
(Concluded) | |
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A Phase III Randomized Controlled Trial of Community Mobilization, Mobile Testing, Same-Day Results, and Post-Test Support for HIV in Sub-Saharan Africa and Thailand |
(Participants Off Study & Primary Analysis Complete) | |
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Feasibility of a community-level, multi-component intervention for Black MSM in preparation for a Phase IIB community-level randomized trial to test the efficacy of the intervention in reducing HIV incidence among Black MSM |
(Closed to Follow Up) | |
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Feasibility and Acceptability Study of an Individual-Level Behavioral Intervention for Individuals with Acute and Early HIV-Infection |
(Closed) | |
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Preparing for international prevention trials involving HIV-infected individuals in care settings |
(Closed to Accrual) | |
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The Women’s HIV SeroIncidence Study (ISIS) |
(Closed to Follow Up) | |
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A Phase II, Randomized, Open-Label, Pharmacokinetic and Behavioral Study of the Use of Intermittent Oral Emtricitabine/Tenofovir Disoproxil Fumarate Pre-Exposure Prophylaxis (PrEP) |
(Enrolling) | |
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Effects of cash transfer for the prevention of HIV in young South African women |
(Closed to Accrual) |
Substance Use
HIV Prevention Preparedness Study |
( Concluded ) | |
A Phase III Randomized Study to Evaluate the Efficacy of a Network-oriented Peer Educator Intervention for the Prevention of HIV Transmission Among Injection Drug Users And Their Network Members |
( Concluded ) | |
A Phase III randomized controlled trial to evaluate the efficacy of drug treatment and death in prevention of HIV infection and death among opiate dependent injectors |
( Closed to Follow Up ) |
Microbicide
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Condom Promotion and Counseling Study |
(Concluded) | |
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Male Tolerance Study of BufferGel and PRO 2000/5 Gel (P) |
(Concluded) | |
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Phase II/IIb Safety and Effectiveness Study of the Vaginal Microbicides BufferGel and 0.5% PRO2000/5 Gel (P) for the Prevention of HIV Infection in Women |
(Concluded) | |
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A Phase I Safety and Acceptability Study of the Investigational Vaginal Microbicide PRO 2000/5 Gel (P) |
(Concluded) | |
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Phase I Safety and Acceptability Study of the Vaginal Microbicide 6% Cellulose Sulfate Gel Among HIV-Infected Women |
(Concluded) | |
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Phase I Safety and Acceptability Study of the Vaginal Microbicide Agent PMPA Gel |
(Concluded) | |
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HIV Prevention Preparedness Study |
(Concluded) | |
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Characterization of Baseline Mucosal Indices of Injury and Inflammation in Men for Use in Rectal Microbicide Trials |
(Concluded) | |
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Phase II Expanded Safety and Acceptability Study of the Vaginal Microbicide 1% Tenofovir Gel |
(Concluded) |
Perinatal
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A Phase IIB Trial to Determine the Efficacy of Oral AZT and the Efficacy of Oral Nevirapine for the Prevention of Vertical Transmission of HIV-1 Infection in Pregnant Ugandan Women and Their Neonates |
(Concluded) | |
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Phase III Trial of Antibiotics to Reduce Chorioamnionitis-Related Perinatal HIV Transmission |
(Concluded) | |
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A Phase I Study to Evaluate the Safety and Immunogenicity of ALVAC-HIV vCP1521 in Infants Born to HIV-1 Infected Women in Uganda |
(Participants Off Study & Primary Analysis Complete) | |
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Phase III Trial to Determine the Efficacy and Safety of an Extended Regimen of Nevirapine in Infants Born to HIV Infected Women to Prevent Vertical HIV Transmission During Breastfeeding |
(Participants Off Study & Primary Analysis Complete) | |
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A Population-based Randomized Trial of Targeted Versus Combined Nevirapine Access to Improve Drug Coverage in Settings of High HIV Prevalence |
(Withdrawn) | |
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A Phase I Open Label Trial of the Safety and Pharmacokinetics of Tenofovir Disoproxil Fumarate in HIV-1 Infected Pregnant Women and their Infants |
(Closed to Follow Up) |
STI Control
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HIV Prevalence, Incidence, and HSV-2 Prevalence Among High-Risk MSM in Perú |
(Concluded) | |
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A Phase III, randomized, double-blind, placebo-controlled trial of acyclovir for the reduction of HIV acquisition among high risk HSV-2 seropositive, HIV-seronegative individuals |
(Concluded) | |
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Ancillary Study: Prospective Cohort Study of HPTN 039 Seroconverters: The Effect of HSV-2 Suppression on HIV-1 Viral Set Point |
(Concluded) |
