HPTN 062

Feasibility and Acceptability Study of an Individual-Level Behavioral Intervention for Individuals with Acute and Early HIV-Infection

Study Summary
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What is HPTN 062?

HPTN 062 was a research study conducted in Lilongwe, Malawi to evaluate the acceptability and feasibility of an enhanced, individual-level counseling intervention for individuals in the acute and early phase of HIV infection aimed at reducing risk behaviors.

Who participated in the study?

A total of 28 participants diagnosed with acute HIV infection (AHI) were randomized to receive either brief education alone, or the brief education plus the Motivational Interviewing (MI)-based intervention, called Uphungu Wanga.

What happened during the study?

Participants in Uphungu Wanga received four sessions delivered on the day of diagnosis, three days later and at weeks 1 and 2 with a booster session at week 8; participants were followed for 24 weeks from diagnosis. An interviewer administered quantitative questionnaire was conducted at baseline and at weeks 2, 4, 8, 12, 16, 20 and 24. Semi-structured qualitative interviews (SSI) were conducted at weeks 2, 8, 12, and 24.


The majority of participants in both arms reported rapid and sustained behavior change following diagnosis with acute HIV infection. Very few participants reported having sex without a condom after diagnosis. Participants reported a trend towards fewer sex partners and abstaining from sex during study follow-up. Participants in the MI-based arm provided concrete examples of risk reduction strategies in the SSIs while those in the brief education arm primarily described reducing risk behavior, suggesting that the MI-based group may have acquired more risk reduction skills.

Study Documents

HPTN 062 Version 3.0

HPTN 062 Version 2.0