HPTN 063

Preparing for international prevention trials involving HIV-infected individuals in care settings

Study Summary
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What is HPTN 063?

HPTN 063 was a research study to conduct the preparatory research needed to design a behavioral intervention to decrease sexual transmission risk behaviors in HIV-infected individuals in care and to determine whether a similar intervention structure could be used across various sexual risk groups and cultural settings.

Who participated in the study?

A total of 751 HIV-infected participants (200 MSM in Brazil and Thailand, 300 heterosexual women, and 251 heterosexual men in Brazil, Thailand and Zambia, who had reported recent (within in the last three months) HIV sexual transmission risk behavior.

What happened during the study?

Study participants were enrolled to complete five quarterly quantitative surveys over the course of a year, and provided specimens for sexually transmitted infection analysis. A subset of participants was enrolled for qualitative interviews including community members/stakeholders and a subset of the HIV-infected participants from the quantitative survey.


By comparing the data across the sites and risk groups, we identified commonalities and variations in participants’ sexual practices, attitudes towards sex, and sexual relationships. The results of these qualitative data are presented according to three themes: (1) protective behaviors; (2) barriers to engaging in sexual safety; and (3) HIV stigma and sexual partnerships.

1. Participants described many changes in their sexual behavior as a consequence of becoming infected with HIV, including: reduction in sexual activity; increased focus on condom use; and engagement in lower-risk sexual activities. While several shared experiences across the three risk groups (MSW, WSM, and MSM) and sites (Brazil, Thailand, and Zambia) emerged, the data also reflected some notable distinctions.

2. Most of the participants found consistent condom use to be challenging. One of the primary sources of difficulty was that casual and primary sex partners viewed condomless sex as ‘normal’.

3. Individuals living with HIV/AIDS at all sites discussed the effects of HIV on relationships with sex partners. HIV stigma was the most common thread in discussions about relationships with sex partners. A significant theme, especially among WSM, was the need to avoid primary intimate sexual relationships because of worry about how a past or potential partner would react after HIV status disclosure.

Study Documents