Form Approved Through 8/31/2015	OMB No. 0925-0001

Department of Health and Human Services
Public Health Services
Grant Application
Do not exceed character length restrictions indicated.	LEAVE BLANK—FOR PHS USE ONLY.	
	Type	Activity	Number	
	Review Group	Formerly	
	Council/Board (Month, Year)	Date Received	
1.   TITLE OF PROJECT (Do not exceed 81 characters, including spaces and punctuation.)	
2.   RESPONSE TO SPECIFIC REQUEST FOR APPLICATIONS OR PROGRAM ANNOUNCEMENT OR SOLICITATION	NO	YES
(If “Yes,” state number and title)
Number:	Title:	
3. PROGRAM DIRECTOR/PRINCIPAL INVESTIGATOR	
3a. NAME (Last, first, middle)	3b. DEGREE(S)	3h.  eRA Commons User Name	
3c. POSITION TITLE	3d. MAILING ADDRESS (Street, city, state, zip code)

E-MAIL ADDRESS:	
3e. DEPARTMENT, SERVICE, LABORATORY, OR EQUIVALENT		
3f.  MAJOR SUBDIVISION		
3g. TELEPHONE AND FAX (Area code, number and extension)

TEL:	FAX:		
4.   HUMAN SUBJECTS RESEARCH

No	Yes	4a. Research Exempt	If “Yes,” Exemption No.

No	Yes	
4b. Federal-Wide Assurance No.	4c. Clinical Trial

No	Yes	4d. NIH-defined Phase III Clinical Trial

No	Yes	
5. VERTEBRATE ANIMALS	No	Yes	5a. Animal Welfare Assurance No.	
6.   DATES OF PROPOSED PERIOD OF SUPPORT (month, day, year—MM/DD/YY)	7.   COSTS REQUESTED FOR INITIAL BUDGET PERIOD	8.   COSTS REQUESTED FOR PROPOSED PERIOD OF SUPPORT	
From	Through	7a. Direct Costs ($)   
18,371	7b. Total Costs ($)
25,369	8a. Direct Costs ($)
48,192	8b. Total Costs ($)
62,646	
9.   APPLICANT ORGANIZATION Name

Address	10. TYPE OF ORGANIZATION
Public:	® 	Federal	State	Local

Private:    ® 	Private Nonprofit

For-profit: ® 	General	Small Business
Woman-owned	Socially and Economically Disadvantaged	
	11. ENTITY IDENTIFICATION NUMBER	
	DUNS NO.	Cong. District	
12. ADMINISTRATIVE OFFICIAL TO BE NOTIFIED IF AWARD IS MADE Name

Title

Address

Tel:	FAX: E-Mail:	13. OFFICIAL SIGNING FOR APPLICANT ORGANIZATION Name

Title

Address

Tel:	FAX: E-Mail:	
14. APPLICANT ORGANIZATION CERTIFICATION AND ACCEPTANCE: I certify that the statements herein are true, complete and accurate to the best of my knowledge, and accept the obligation to comply with Public Health Services terms and conditions if a grant is awarded as a result of this application. I am aware that any false, fictitious, or fraudulent statements or claims may subject me to criminal, civil, or administrative penalties.	SIGNATURE OF OFFICIAL NAMED IN 13.
(In ink. “Per” signature not acceptable.)

	DATE	

Program Director/Principal Investigator (Last, First, Middle):   Hunt, Casey Morgan

11/30/2019

06/01/2019			

DETAILED BUDGET FOR INITIAL BUDGET PERIOD DIRECT COSTS ONLY

FROM	THROUGH

List PERSONNEL (Applicant organization only)
Use Cal, Acad, or Summer to Enter Months Devoted to Project
Enter Dollar Amounts Requested (omit cents) for Salary Requested and Fringe Benefits

NAME	
ROLE ON PROJECT	
Cal. Mnths	
Acad. Mnths	
Summer
Mnths	
INST.BASE SALARY	
SALARY REQUESTED	
FRINGE BENEFITS	

TOTAL	

Hunt, Casey Morgan	
HPTN Scholar	
1			
$100,000	
$8,333	
$2,083	
$10,416	

									

									

SUBTOTALS	$8,333	$2,083	$10,416	
CONSULTANT COSTS		
EQUIPMENT (Itemize)
•	laptop	
      $1,500	
SUPPLIES (Itemize by category)		
TRAVEL
(1)	HPTN Meeting in Washington, DC (2) Mid-Year Retreat (3) Mentor Meetings	
      $7,570	
INPATIENT CARE COSTS		
OUTPATIENT CARE COSTS		
ALTERATIONS AND RENOVATIONS (Itemize by category)		
OTHER EXPENSES (Itemize by category)
•	Telecommunication Costs
•	Photocopying
•	General Office Supplies	

      $375	
CONSORTIUM/CONTRACTUAL COSTS	DIRECT COSTS		

SUBTOTAL DIRECT COSTS FOR INITIAL BUDGET PERIOD (Item 7a, Face Page)	
$  19,861	
CONSORTIUM/CONTRACTUAL COSTS	FACILITIES AND ADMINISTRATIVE COSTS		
TOTAL DIRECT COSTS FOR INITIAL BUDGET PERIOD	$  19,861	
PHS 398 (Rev. 08/12 Approved Through 8/31/2015)	OMB No. 0925-0001
Page  		Form Page 4

Program Director/Principal Investigator (Last, First, Middle):   Hunt, Casey Morgan

11/30/2020

12/1/2019

DETAILED BUDGET FOR SECOND FUNDING 
    BUDGET PERIOD DIRECT COSTS ONLY

FROM	THROUGH

List PERSONNEL (Applicant organization only)
Use Cal, Acad, or Summer to Enter Months Devoted to Project
Enter Dollar Amounts Requested (omit cents) for Salary Requested and Fringe Benefits

NAME	
ROLE ON PROJECT	
Cal. Mnths	
Acad. Mnths	
Summer
Mnths	
INST.BASE SALARY	
SALARY REQUESTED	
FRINGE BENEFITS	

TOTAL	

Hunt, Casey Morgan	
HPTN Scholar	
2			
$100,000	
$16,667	
$4,167	
$20,834	

									

									

SUBTOTALS	$16,667	$4,167	$20,834	
CONSULTANT COSTS		
EQUIPMENT (Itemize)

SUPPLIES (Itemize by category)		
TRAVEL
(1) HPTN Meeting in Washington, DC (2) HIV/AIDS Nat’l Meeting (3) Mentor MMeetings	
      $7,497	
INPATIENT CARE COSTS		
OUTPATIENT CARE COSTS		
ALTERATIONS AND RENOVATIONS (Itemize by category)		
OTHER EXPENSES (Itemize by category)

      	
CONSORTIUM/CONTRACTUAL COSTS	DIRECT COSTS		

SUBTOTAL DIRECT COSTS FOR INITIAL BUDGET PERIOD (Item 7a, Face Page)	
$  28,331	
CONSORTIUM/CONTRACTUAL COSTS	FACILITIES AND ADMINISTRATIVE COSTS		
TOTAL DIRECT COSTS FOR INITIAL BUDGET PERIOD	$  28,331	
PHS 398 (Rev. 08/12 Approved Through 8/31/2015)	OMB No. 0925-0001
Page  		Form Page 4

Program Director/Principal Investigator (Last, First, Middle):  Hunt, Casey Morgan

BUDGET JUSTIFICATION for Initial Budget Period (6/1/2019 to 11/30/2019)
PERSONNEL
  HPTN Scholar Salary Supplement: The HPTN Scholar salary supplement requests funding to cover

We request  	% Salary Supplement for 18 months: $ 	 TRAVEL
Travel Expenses: We are requesting travel funds for travels to HPTN Scholars related meetings,
conferences, and visiting mentorship with (Your HPTN Mentor) at (Institution)	. Travel funds requested as outlined below include round trip airfare, hotel, meals, ground transportation, and travel-related incidentals. We request a total travel budget for attendance of the meetings as outlined below:  $ 	

HPTN ANNUAL MEETINGS (2 MEETINGS, 4 DAYS EACH): $ 	.
Attendance of these annual HPTN meetings are requirement of the HPTN Scholars Program. Estimates are based on travel to Washington, DC which was the previous location of this meeting.

Travel from  		to Washington DC (RT): $ 	/ trip x 2 trips = $ 	 Hotel: $ 	/ day x 4 days x 2 trips= $ 	
Meals: $ 	/day x 4 days x 2 trips = $ 	
Ground transportation: $ 		/ trip x 2 trip = $ 	 Travel costs incidentals: $ 	/ trip x 2 trip =$ 		

HPTN SCHOLARS RETREAT (1 MEETING, 3 DAYS): $ 	.
Attendance to this retreat is a requirement of the HPTN Scholars Program. Estimates are based on travel to Seattle, WA which was the previous location of this meeting.

Travel from  		to Seattle, WA (RT): $ 	x1trip = $ 	 Hotel: $ 	/ day x 3 days = $ 		
Meals: $ 	/day x 3 days = $ 			 Ground transportation: $ 	/trip = $ 		 Travel costs incidentals: $ 		/trip =$ 			
  
Travel to Mentor’s site: $___________
       Travel from ___________ to __________ (RT): $______x1trip = $__________
       Hotel: $______/ day x 3 days = $________
       Meals $______/ day x 3 days = $________
       Ground transportation: $________/ trip = $________
       Travel costs incidentals: $_______/ trip = $________

Additional relevant conference during the program (IAS, R4P, USCA, etc.): $ 	      Attendance to the  	conference in (month) _______ (year) ______.
Travel from  		to  	_ (RT): $ 	x1trip = $ 	 Hotel: $ 	/ day x 3 days = $ 		
Meals: $ 	/day x 3 days = $ 			 
Ground transportation: $ 	/trip = $ 		 Travel costs incidentals: $ 		/trip =$ 			
Program Director/Principal Investigator (Last, First, Middle):  Hunt, Casey Morgan

BUDGET JUSTIFICATION for Second Budget Funding Period (12/1/2019 to 11/30/2020)
PERSONNEL
  HPTN Scholar Salary Supplement: The HPTN Scholar salary supplement requests funding to cover

We request  	% Salary Supplement for 18 months: $ 	 TRAVEL
Travel Expenses: We are requesting travel funds for travels to HPTN Scholars related meetings,
conferences, and visiting mentorship with (Your HPTN Mentor) at (Institution)	. Travel funds requested as outlined below include round trip airfare, hotel, meals, ground transportation, and travel-related incidentals. We request a total travel budget for attendance of the meetings as outlined below:  $ 	

HPTN ANNUAL MEETINGS (2 MEETINGS, 4 DAYS EACH): $ 	.
Attendance of these annual HPTN meetings are requirement of the HPTN Scholars Program. Estimates are based on travel to Washington, DC which was the previous location of this meeting.

Travel from  		to Washington DC (RT): $ 	/ trip x 2 trips = $ 	 Hotel: $ 	/ day x 4 days x 2 trips= $ 	
Meals: $ 	/day x 4 days x 2 trips = $ 	
Ground transportation: $ 		/ trip x 2 trip = $ 	 Travel costs incidentals: $ 	/ trip x 2 trip =$ 		

Travel to Mentor’s site: $___________
       Travel from ___________ to __________ (RT): $______x1trip = $__________
       Hotel: $______/ day x 3 days = $________
       Meals $______/ day x 3 days = $________
       Ground transportation: $________/ trip = $________
       Travel costs incidentals: $_______/ trip = $________

Additional relevant conference during the program (IAS, R4P, USCA, etc.): $ 	      Attendance to the  	conference in (month) _______ (year) ______.
Travel from  		to  	_ (RT): $ 	x1trip = $ 	 Hotel: $ 	/ day x 3 days = $ 		
Meals: $ 	/day x 3 days = $ 			 
Ground transportation: $ 	/trip = $ 		 Travel costs incidentals: $ 		/trip =$ 			

eRA COMMONS USER NAME (credential, e.g., agency login)

EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.)

INSTITUTION AND LOCATION	DEGREE
(if applicable)	MM/YY	FIELD OF STUDY	

NOTE: The Biographical Sketch may not exceed four pages. Follow the formats and instructions below.

1.	Personal Statement

Briefly describe why your experience and qualifications make you particularly well-suited for your role (e.g., PD/PI, mentor, participating faculty) in the project that is the subject of the application. Within this section you may, if you choose, briefly describe factors such as family care responsibilities, illness, disability, and active duty military service that may have affected your scientific advancement or productivity.

B.  Positions and Honors

List in chronological order previous positions, concluding with the present position. List any honors. Include present membership on any Federal Government public advisory committee.

C.  Selected Peer-reviewed Publications

NIH encourages applicants to limit the list of selected peer-reviewed publications or manuscripts in press to no more than 15. Do not include manuscripts submitted or in preparation. The individual may choose to include selected publications based on recency, importance to the field, and/or relevance to the proposed research. When citing articles that fall under the Public Access Policy, were authored or co-authored by the applicant and arose from NIH support, provide the NIH Manuscript Submission reference number (e.g., NIHMS97531) or the PubMed Central (PMC) reference number (e.g., PMCID234567) for each article. If the PMCID is not yet available because the Journal submits articles directly to PMC on behalf of their authors, indicate “PMC
Journal – In Process.” A list of these Journals is posted at: http://publicaccess.nih.gov/submit_process_journals.htm. Citations that are not covered by the Public Access Policy, but are publicly available in a free, online format may include URLs or PMCID numbers along with the full reference (note that copies of publicly available publications are not accepted as appendix material.)

D.  Research Support

List both selected ongoing and completed research projects for the past three years (Federal or non-Federally- supported). Begin with the projects that are most relevant to the research proposed in the application. Briefly indicate the overall goals of the projects and responsibilities of the key person identified on the Biographical Sketch. Do not include number of person months or direct costs.

OMB No. 0925-0001/0002 (Rev. 8/12 Approved Through 8/31/2015)	Page      	Biographical Sketch Format Page

BIOGRAPHICAL SKETCH
Provide the following information for the Senior/key personnel and other significant contributors in the order listed on Form Page 2.
Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME
Hunt, Morgan Casey

eRA COMMONS USER NAME (credential, e.g., agency login)
huntmc

POSITION TITLE
Associate Professor of Psychology

EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.)

INSTITUTION AND LOCATION	DEGREE
(if applicable)	MM/YY	FIELD OF STUDY	
University of California, Berkeley

University of Vermont

University of California, Berkeley	B.S.

Ph.D. Postdoctoral	05/90

05/96

08/98	Psychology

Experimental
Psychology

Public Health and
Epidemiology	

1.	Personal Statement

The goal of the proposed research is to investigate the interaction between drug abuse and normal aging processes. Specifically, we plan to measure changes in cognitive ability and mental and physical health across a five-year period in a group of older drug users and matched controls. I have the expertise, leadership and motivation necessary to successfully carry out the proposed work. I have a broad background in psychology, with specific training and expertise in key research areas for this application. As a postdoctoral fellow at Berkeley, I carried out ethnographic and survey research and secondary data analysis on psychological aspects of drug addiction. At the Division of Intramural Research at the National Institute on
Drug Abuse (NIDA), I expanded my research to include neuropsychological changes associated with addiction. As PI or co-Investigator on several university- and NIH-funded grants, I laid the groundwork for the proposed research by developing effective measures of disability, depression, and other psychosocial factors relevant to the aging substance abuser, and by establishing strong ties with community providers that will make it possible to recruit and track participants over time. In addition, I successfully administered the projects (e.g. staffing, research protections, budget), collaborated with other researchers, and produced several peer-reviewed publications from each project. As a result of these previous experiences, I am aware of the importance of frequent communication among project members and of constructing a realistic research plan, timeline, and budget. The current application builds logically on my prior work, and I have chosen co-investigators (Drs. Gryczynski and Newlin) who provide additional expertise in cognition, gerontology and geriatrics. During 2005-
2006 my career was disrupted due to family obligations. However, upon returning to the field I immediately resumed my research projects and collaborations and successfully competed for NIH support. In summary, I have a demonstrated record of accomplished and productive research projects in an area of high relevance for our aging population, and my expertise and experience have prepared me to lead the proposed project.

B. Positions and Honors

Positions and Employment
1998-2000	Fellow, Division of Intramural Research, National Institute of Drug Abuse, Bethesda, MD
2000-2002	Lecturer, Department of Psychology, Middlebury College, Middlebury, VT
2001-	Consultant, Coastal Psychological Services, San Francisco, CA

OMB No. 0925-0001/0002 (Rev. 8/12 Approved Through 8/31/2015)	Page  5 	Biographical Sketch Format Page

2002-2005	Assistant Professor, Department of Psychology, Washington University, St. Louis, MO
2007-	Associate Professor, Department of Psychology, Washington University, St. Louis, MO

Other Experience and Professional Memberships
1995-	Member, American Psychological Association
1998-	Member, Gerontological Society of America
1998-	Member, American Geriatrics Society
2000-	Associate Editor, Psychology and Aging
2003-	Board of Advisors, Senior Services of Eastern Missouri
2003-05	NIH Peer Review Committee: Psychobiology of Aging, ad hoc reviewer
2007-11	NIH Risk, Adult Addictions Study Section, member

Honors
2003	Outstanding Young Faculty Award, Washington University, St. Louis, MO
2004	Excellence in Teaching, Washington University, St. Louis, MO
2009	Award for Best in Interdisciplinary Ethnography, International Ethnographic Society

C. Selected Peer-reviewed Publications (Selected from 42 peer-reviewed publications)

Most relevant to the current application
1.  Merryle, R.J. & Hunt, M.C. (2004). Independent living, physical disability and substance abuse among the elderly. Psychology and Aging, 23(4), 10-22.
2.  Hunt, M.C., Jensen, J.L. & Crenshaw, W. (2007). Substance abuse and mental health among community- dwelling elderly. International Journal of Geriatric Psychiatry, 24(9), 1124-1135.
3.  Hunt, M.C., Wiechelt, S.A. & Merryle, R. (2008). Predicting the substance-abuse treatment needs of an aging population. American Journal of Public Health, 45(2), 236-245. PMCID: PMC9162292
4.  Hunt, M.C., Newlin, D.B. & Fishbein, D. (2009). Brain imaging in methamphetamine abusers across the life-span. Gerontology, 46(3), 122-145.
5.  Hunt, M.C. & Sher, K.A. (2009). Successful intervention models for older drug-abusers: Research across the life-span. American Psychologist, in press. NIHMSID: NIHMS99135

Additional recent publications of importance to the field (in chronological order)
1.  Gryczynski, J., Shaft, B.M., Merryle, R., & Hunt, M.C. (2002). Community based participatory research with late-life addicts. American Journal of Alcohol and Drug Abuse, 15(3), 222-238.
2.  Shaft, B.M., Hunt, M.C., Merryle, R., & Venturi, R. (2003). Policy implications of genetic transmission of alcohol and drug abuse in female nonusers. International Journal of Drug Policy, 30(5), 46-58.
3.  Hunt, M.C., Marks, A.E., Shaft, B.M., Merryle, R., & Jensen, J.L. (2004). Early-life family and community characteristics and late-life substance abuse. Journal of Applied Gerontology, 28(2),26-37.
4.  Hunt, M.C., Merryle, R. & Jensen, J.L. (2005). The effect of social support networks on morbidity among elderly substance abusers. Journal of the American Geriatrics Society, 57(4), 15-23.
5.  Hunt, M.C., Pour, B., Marks, A.E., Merryle, R. & Jensen, J.L. (2005). Aging out of methadone treatment.
American Journal of Alcohol and Drug Abuse, 15(6), 134-149.
6.  Hunt, M.C., Marks, A.E., Venturi, R., Crenshaw, W. & Ratonian, A. (2007). Community-based intervention strategies for reducing alcohol and drug abuse in the elderly. Addiction, 104(9), 1436-1606. PMCID: PMC9000292
7.  Merryle, R. & Hunt, M.C. (2007). Randomized clinical trial of cotinine in older nicotine addicts. Age and
Ageing, 38(2), 9-23. PMCID: PMC9002364
8.  Hunt, M.C., Jensen, J.L. & Merryle, R. (2008). The aging addict: ethnographic profiles of the elderly drug user. NY, NY: W. W. Norton & Company.
9.  Hunt, M.C. (2009). Contrasting ethnicity with race in the older alcoholic. The Journals of Gerontology
Series B: Psychological Sciences and Social Sciences, in press. PMCID: PMC Journal – In Process.
10. Hunt, M.C. (2009). Intervening successfully with the older methadone patient. Journal of Applied
Gerontology, 13(4), 67-79.

D. Research Support

Ongoing Research Support

R01 DA942367-03	Hunt (PI)	09/01/08-08/31/13
Health trajectories and behavioral interventions among older substance abusers
The goal of this study is to compare the effects of two substance abuse interventions on health outcomes in an urban population of older opiate addicts.
Role: PI

R01 MH922731-05	Merryle (PI)	12/15/07-11/30/12
Physical disability, depression and substance abuse in the elderly
The goal of this study is to identify disability and depression trajectories and demographic factors associated with substance abuse in an independently-living elderly population.
Role: Co-Investigator

Faculty Resources Grant, Washington University	08/15/09-08/14/11
Opiate Addiction Database
The goal of this project is to create an integrated database of demographic, social and biomedical information for homeless opiate abusers in two urban Missouri locations, using a number of state and local data sources.

Completed Research Support

K02 AG442898	Hunt (PI)	02/01/02-01/31/05
Drug Abuse in the Elderly
Independent Scientist Award: to develop a drug addiction research program with a focus on substance abuse among the elderly.
Role: PI

R21 AA998075	Hunt (PI)	01/01/02-12/31/04
Community-based intervention for alcohol abuse
The goal of this project was to assess a community-based strategy for reducing alcohol abuse among older individuals.
Role: PI

For New and Renewal Applications (PHS 398) – DO NOT SUBMIT UNLESS REQUESTED

 	PHS 398 OTHER SUPPORT 	

Provide active and pending support for all senior/key personnel. Other Support includes all financial resources, whether Federal, non-Federal, commercial or institutional, available in direct support of an individual’s research endeavors, including but not limited to research grants, cooperative agreements, contracts, and/or institutional awards. Training awards, prizes, or gifts do not need to be included.

There is no “form page” for other support. Information on other support should be provided in the format shown below, using continuation pages as necessary. Include the principal investigator’s name at the top and number consecutively with the rest of the application. The sample below is intended to provide guidance regarding the type and extent of information requested.
For instructions and information pertaining to the use of and policy for other support, see Other Support in the Supplemental Instructions, Part III,
Policies, Assurances, Definitions, and Other Information.
Effort devoted to projects must be measured using person months. Indicate calendar, academic, and/or summer months associated with each project.

NAME OF INDIVIDUAL
ACTIVE/PENDING
Project Number (Principal Investigator) Source
Title of Project (or Subproject)

The major goals of this project are… OVERLAP (summarized for each individual)

Format

Dates of Approved/Proposed Project
Annual Direct Costs

Samples

Person Months (Cal/Academic/ Summer)

ANDERSON, R.R.
ACTIVE
2 R01 HL 00000-13 (Anderson)	3/1/1997 – 2/28/2002	3.60 calendar
NIH/NHLBI	$186,529
Chloride and Sodium Transport in Airway Epithelial Cells

The major goals of this project are to define the biochemistry of chloride and sodium transport in airway epithelial cells and clone the gene(s) involved in transport.

5 R01 HL 00000-07 (Baker)	4/1/1994 – 3/31/2002	1.20 calendar	
NIH/NHLBI	$122,717		
Ion Transport in Lungs			

The major goal of this project is to study chloride and sodium transport in normal and diseased lungs.

R000 (Anderson)	9/1/1996 – 8/31/2002	1.20 calendar	
Cystic Fibrosis Foundation	$43,123		
Gene Transfer of CFTR to the Airway Epithelium			

The major goals of this project are to identify and isolate airway epithelium progenitor cells and express human CFTR in airway epithelial cells.

PENDING
DCB 950000 (Anderson)	12/01/2002 – 11/30/2004	2.40 calendar	
National Science Foundation	$82,163		
Liposome Membrane Composition and Function			

The major goals of this project are to define biochemical properties of liposome membrane components and maximize liposome uptake into cells.

OVERLAP
There is scientific overlap between aim 2 of NSF DCB 950000 and aim 4 of the application under consideration. If both are funded, the budgets will be adjusted appropriately in conjunction with agency staff.

RICHARDS, L.
NONE

HERNANDEZ, M.
ACTIVE
5 R01 CA 00000-07 (Hernandez)	4/1/1995 – 3/31/2002	3.60 academic	
NIH/NCI	$110,532		
Gene Therapy for Small Cell Lung Carcinoma			

The major goals of this project are to use viral strategies to express the normal p53 gene in human SCLC
cell lines and to study the effect on growth and invasiveness of the lines.

5 P01 CA 00000-03 (Chen)	7/1/2000 – 6/30/2002	1.80 academic	
NIH/NCI	$104,428 (sub only)	3.00 summer	
Mutations in p53 in Progression of Small Cell Lung Carcinoma

The major goals of this subproject are to define the p53 mutations in SCLC and their contribution to tumor progression and metastasis.

BE 00000 (Hernandez)	9/1/1996 – 8/31/2002	1.80 academic	
American Cancer Society	$86,732		
p53 Mutations in Breast Cancer			

The major goals of this project are to define the spectrum of p53 mutations in human breast cancer samples and correlate the results with clinical outcome.

OVERLAP
Potential commitment overlap for Dr. Hernandez between 5 R01 CA 00000-07 and the application under consideration. If the application under consideration is funded with Dr. Hernandez committed at 3.60 person months, Dr. Hernandez will request approval to reduce her months on the NCI grant.

BENNETT, P.
ACTIVE
Investigator Award (Bennett)	9/1/1999 – 8/31/2002	9.00 calendar
Howard Hughes Medical Institute	$581,317
Gene Cloning and Targeting for Neurological Disease Genes
This award supports the PI’s program to map and clone the gene(s) implicated in the development of
Alzheimer’s disease and to target expression of the cloned gene(s) to relevant cells.

OVERLAP: None

Program Director/Principal Investigator (Last, First, Middle):

CHECKLIST
TYPE OF APPLICATION (Check all that apply.)

NEW application. (This application is being submitted to the PHS for the first time.)

RESUBMISSION of application number:
(This application replaces a prior unfunded version of a new, renewal, or revision application.)

	RENEWAL of grant number:  	
(This application is to extend a funded grant beyond its current project period.)

REVISION to grant number:
(This application is for additional funds to supplement a currently funded grant.)

CHANGE of program director/principal investigator. Name of former program director/principal investigator: CHANGE of Grantee Institution.   Name of former institution:
FOREIGN application	Domestic Grant with foreign involvement	List Country(ies) Involved:

INVENTIONS AND PATENTS (Renewal appl. only)	No	Yes

If “Yes,”	Previously reported	Not previously reported
1. PROGRAM INCOME (See instructions.)
All applications must indicate whether program income is anticipated during the period(s) for which grant support is request. If program income is anticipated, use the format below to reflect the amount and source(s).

Budget Period	Anticipated Amount	Source(s)	
			
2.  ASSURANCES/CERTIFICATIONS (See instructions.)
In signing the application Face Page, the authorized organizational representative agrees to comply with the policies, assurances and/or certifications listed in the application instructions when applicable. Descriptions of individual assurances/certifications are provided in Part III and listed in Part I, 4.1 under Item 14. If unable to certify compliance, where applicable, provide an explanation and place it after this page.

3. FACILITIES AND ADMINSTRATIVE COSTS (F&A)/ INDIRECT COSTS. See specific instructions.

DHHS Agreement dated:      MM/DD/YYYY	No Facilities And Administrative Costs Requested. DHHS Agreement being negotiated with		Regional Office.
No DHHS Agreement, but rate established with	Date
CALCULATION* (The entire grant application, including the Checklist, will be reproduced and provided to peer reviewers as confidential information.)

a. Initial budget period:	Amount of base $	   18,361	x Rate applied              30.00	% = F&A costs	$               5,508

b. 02 year	Amount of base $                29,821	x Rate applied              30.00	% = F&A costs	$              8,946

c. 03 year	Amount of base $	x Rate applied	% = F&A costs	$

d. 04 year	Amount of base $	x Rate applied	% = F&A costs	$

e. 05 year	Amount of base $	x Rate applied	% = F&A costs	$

*Check appropriate box(es):

TOTAL F&A Costs	$

Salary and wages base		Modified total direct cost base	Other base (Explain)

Off-site, other special rate, or more than one rate involved (Explain)
Explanation (Attach separate sheet, if necessary.):

4. DISCLOSURE PERMISSION STATEMENT: If this application does not result in an award, is the Government permitted to disclose the title of your proposed project, and the name, address, telephone number and e-mail address of the official signing for the applicant organization, to
organizations that may be interested in contacting you for further information (e.g., possible collaborations, investment)?	Yes	No
PHS 398 (Rev. 08/12 Approved Through 8/31/2015)	OMB No. 0925-0001
Page  		Checklist Form Page

Attachment 1: Detailed Budget Assumptions for Illustrative Purposes for New Scholars
	01 June– 30	01 Dec 2019 – 30	Total	
	November 2019	Nov 2020 (12	June 2019-Nov	
Salary		(6 months)	months)	2020	
Name	TBD				

Role

Scholar in
training

Inst. Base Salary	$100,000
Salary Request	15% x 18 mos	$8,333	$16,667	$25,000
Fringe	25%	$2,083	$4,167	$6,250
Total	$10,416	$20,834	$31,250

Travel

HPTN Meetings (2) at start and at 12 months (approximately 4 days)	
Airfare: New York--DC	$500 / RT	$500	$500	$1000	
Per Diem: DC	$295 / Day	$1180	$1180	$2360	
Incidental travel costs
(communications, etc)	
$50 / trip	
$50	
$50	
$100	
Airport Transfers	$100 / trip	$100	$100	$200	
HIV/AIDS National Meeting (N=1; 3 days)	
Airfare: New York--Atlanta	$700 / RT		$700	$700	
Per Diem: Atlanta Incidental travel costs (communications, etc)	$189 / day

$50 / trip		$567

$50	$567

$50	
Airport Transfers	$100 / trip		$100	$100	
HPTN Scholar Mid-Year Meeting (N=1; 3 days)	
Airfare: New York-- Seattle	$500 / RT	          $500		$500	
Per Diem: Seattle Incidental travel costs (communications, etc)	$280 / day

$50 / trip                           	         $840

            $50	
	$840

$50	
Airport Transfers	$100 / trip	         $100		$100	
Meetings with out of town mentor (4 trips of 5 days each) – if applicable	
Airfare: New York--DC	$500 / RT	$1000	$1000	$2000	
Per Diem:DC	$295 / day	$2950	$2950	$5900	
Incidental travel costs
(communications, etc)	$50 / trip	
$100	
$100	
$200	
Airport Transfers	$100 / trip	$200	$200	$400	
Other Direct Costs – if applicable				
Telecommunication costs for monthly calls	        $125		$125	
Photocopying of key prevention articles, manuals, etc	        $125		$125	
General office supplies: books; software
Laptop
	        $125
       $1500		$125
            $1500

Total Direct Costs	
$19,861	
$28,331
	
$48,192	

Indirect Costs (avg. 30%)	
$5,508	
$8,946	
$14,454	

TOTAL COSTS	
$25,369	
$37,277	
$62,646

Assumptions: NY as home base; DC for Annual Meeting; Atlanta for National Meeting; Seattle for mid-year meeting; Mentor in DC, salary support at 15%, fringe at 25%, institutional indirect of 30%.