The PEC is responsible for overseeing a continuous and comprehensive evaluation of the HPTN. The PEC designs and directs implementation and reporting of the internal evaluation of the HPTN. This includes assessing performance of the CTUs as well as key organizations and entities that are also part of the HPTN (e.g., Leaderships and Operations Center (LOC), SDMC, Laboratory Center (LC) and protocol teams).

The goal of the evaluation is to provide data to assist leadership in making any decisions or changes necessary to improve HPTN functioning. In regard to the CTUs, the primary purpose of the evaluation is to provide data to determine if the sites are contributing effectively to the protocols assigned and to elicit corrective action, if necessary, so that all sites are functioning at peak performance level.