About the HPTN

Mission Statement

The HPTN is dedicated to the discovery and development of new and innovative research strategies to reduce the acquisition and transmission of HIV.

The HIV Prevention Trials Network (HPTN) is a worldwide collaborative clinical trials network that brings together investigators, ethicists, community and other partners to develop and test the safety and efficacy of interventions designed to prevent the acquisition and transmission of HIV. HPTN studies evaluate new HIV prevention interventions and strategies in populations and geographical regions that bear a disproportionate burden of infection.

The HPTN research agenda is focused primarily on the use of integrated strategies: use of antiretroviral drugs (antiretroviral therapy and pre-exposure prophylaxis); interventions for substance abuse, particularly injection drug use; behavioral risk reduction interventions and structural interventions. The HPTN is committed to the highest ethical standards for its clinical trials and recognizes the importance of community engagement in all phases of the research process.

The HPTN was established in 2000, building on the work of the HIV Network for Prevention Trials (HIVNET). HPTN’s Leadership and Operations Center (LOC), is based at FHI 360, Durham, NC. Its Laboratory Center (LC) is at Johns Hopkins University, Baltimore, MD and its Statistical and Data Management Center (SDMC) is housed within the Statistical Center for HIV/AIDS Research and Prevention (SCHARP) at the Fred Hutchinson Cancer Research Center in Seattle, Washington.

HPTN receives its funding from three NIH institutes: the National Institute of Allergy and Infectious Diseases, the National Institute of Mental Health and the National Institute on Drug Abuse.

Fact Sheets

HPTN Fact Sheet


The HPTN Leadership and Operations Center (LOC)

The HPTN Statistical and Data Management Center (SDMC)

Conversations with the HPTN

Sergii Dvoriak, MD, DMedSci, is a protocol team member for the HPTN 074 study and senior researcher at the Ukrainian Institute on Public Health Policy (UIPHP) in Kiev, Ukraine.

Neetha Shagan Morar, MS, is the senior research manager for the South African Medical Research Council (SAMRC) HIV Prevention Research Unit in Durban, South Africa.

Clemensia Nakabiito, MBChB, Mmed, is the HPTN 084 investigator of record at the Makerere University Johns Hopkins University Research Collaboration (MUJHU) in Kampala, Uganda.

Nomtha Bell-Mandla, MPH, is a project manager and study coordinator at the Desmond Tutu TB Centre (DTTC) at Stellenbosch University in Cape Town, South Africa.