The HPTN works with five distinct study populations: adolescents and young people; cisgender men who have sex with men (MSM); cisgender women; people who inject drugs; and transgender women who have sex with men.

Adolescents and Young People

Adolescents and young peopleAdolescents are defined as people between 10 and 19 years old, while young people are defined as those between 10 and 24 years old.

There are 5 million youth living with HIV around the world. In addition, more than 30% of all new HIV infections globally are estimated to occur among youth ages 15 to 25 years.



Current HPTN Studies that Focus on Adolescents and Young People:

HPTN 083-01

HPTN 084-01



Cisgender Men Who Have Sex with Men

MSMRates of HIV infection are disproportionately high among cisgender men who have sex with men (MSM) in all regions of the world. This group is 19 times more likely to be living with HIV than the general population.

Current HPTN Studies that Focus on Adolescents and Young People:

HVTN 704/HPTN 085

HPTN 083

HPTN 083-02

HPTN 094

HPTN 096 (In Development)


Cisgender Women

Cisgender WomenCisgender means having a gender identity that matches one’s assigned sex. For example, a cisgender woman is someone assigned female at birth and identifies as a woman.

About 17.4 million adults living with HIV are cisgender women.




Current HPTN Studies that Focus on Cisgender Women:

HVTN 703/HPTN 081

HPTN 082

HPTN 084

HPTN 084-01


People Who Inject Drugs

People Who Inject Drugs - 094 Site TeamAround 13 million people around the globe inject drugs and 1.7 million of them are living with HIV.

People who inject drugs account for approximately 10% of HIV infections globally and 30% of those outside of Africa.




Current HPTN Studies that Focus on People Who Inject Drugs:

HPTN 094

Transgender Women

Transgender WomenTransgender women are around 49 times more likely to be living with HIV than other adults of reproductive age with an estimated worldwide HIV prevalence of 19%. In some countries the HIV prevalence rate in transgender women is 80 times higher than of the general adult population.

In addition, transgender people have low rates of access to health and HIV services due to a range of issues including violence, legal barriers, stigma and discrimination.

Current HPTN Studies that Focus on Transgender Women:

HVTN 704/HPTN 085         HPTN 091

HPTN 083                             HPTN 096

HPTN 083-02