HPTN Feature Stories

Community Insights on Barriers and Lessons Learned (So Far) From Two HPTN Studies Targeting Young People

Community Insights on Barriers and Lessons Learned for Effective HIV Prevention Programs for Young PeopleJuly 2021

By HPTN Communications

In July 2020, HPTN researchers launched the first HPTN study to enroll U.S. adolescents under the age of 18 exclusively. HPTN 083-01 evaluates the safety, tolerability, and acceptability of a pre-exposure prophylaxis (PrEP) regimen containing long-acting injectable cabotegravir (CAB LA) for adolescents assigned male at birth. The U.S.-based study is the first collaboration between the HPTN and the Adolescent Medicine Trials Network for HIV/AIDS Interventions, part of the Eunice Kennedy Shriver National Institute of Child Health and Human Development. A companion study, HPTN 084-01, launched in November 2020. Also known as “LIFT,” this study examines whether injectable cabotegravir for PrEP is safe, tolerable, and acceptable for adolescents assigned female at birth under 18 years of age. LIFT is enrolling study participants at sites in South Africa, Uganda, and Zimbabwe.

Read More

HIV/AIDS at 40: Marking the 40th Anniversary of the Pandemic

40 years of AIDSJune 2021

By HPTN Communications

On June 5, 1981, Morbidity and Mortality Weekly Report, the Centers for Disease Control and Prevention’s weekly report, included an article about five young gay men in Los Angeles treated for a rare form of pneumonia. This syndrome became known as gay-related immune deficiency, which would later be called acquired immunodeficiency syndrome, or AIDS, caused by the human immunodeficiency virus, or HIV.  

Read More

 

The Role of Proof of Concept Studies in HIV Prevention Research

labOctober 2020

By HPTN Communications

The clinical research process involves a progression of studies that build upon one another. These studies are designed to answer specific research questions. For pharmaceutical product development studies, this includes evaluating dose-response, safety, efficacy and acceptability. Proof-of-concept clinical trials, also known as test-of-concept studies, play an essential role in the product discovery and development process. 

Read More

 

Community Engagement in the Age of COVID-19

COVIDJuly 2020

By HPTN Communications

COVID-19 has affected 213 countries and territories around the world. There have been more than 16 million cases and more than 650,000 deaths worldwide. In a time of fear, uncertainty and doubt, reaching study populations in creative ways has become even more critical given the realities of social distancing and virtual communications.

Read More

 

Introducing New Study Concepts: A Community Engagement Perspective

KisumuApril 2020

By HPTN Communications

When a new study concept is introduced, a critical component of the process is engaging study communities. Helping community members understand the benefits and risks of study participation allows them to make decisions about how they want to support or contribute to a study’s development. Whether a new drug, treatment method or technology, the messaging process is critical, and consultation at the protocol development stage is essential. The community engagement team at the KEMRI Centre for Global Health, aka Kisumu Clinical Research Site (CRS), in Kisumu, Kenya, regularly engage community stakeholders, including women, youth, female sex workers, and men who have sex with men.

Read More

Giving Women Control of HIV Prevention: How Injectable PrEP Could Change Everything

GirlsDecember 1, 2017

By Sinead Delany-Moretlwe

As a South African, HIV prevention is a very real and personal issue. I completed my medical training in South Africa at a time when HIV incidence was rising. The hospital wards were full of young people, including women who should have had futures ahead of them and yet for whom we could do very little. Antiretrovirals were in their infancy and had not yet reached South Africa. That experience for me as a clinician was profound. Even now, it is impossible to ignore the impact that HIV has on women in our region, particularly young women. 

Read More