Fogel JM, Wilson EA, Piwowar-Manning E, Breaud A, Clarke W, Petropoulos C, Moore A, Fraser C, Kosloff B, Shanaube K, van Zyl G, Scheepers M, Floyd S, Bock P, Ayles H, Fidler S, Hayes R, Donnell D, Eshleman SH, HPTN 071 (PopART) Study Team. HIV drug resistance in a community-randomized trial of universal testing and treatment: HPTN 071 (PopART).. J Int AIDS Soc. 2022, 25: e25941. PMC9248006
Universal HIV testing and treatment (UTT) has individual and public health benefits. HPTN 071 (PopART), a community-randomized trial in Zambia and South Africa, demonstrated that UTT decreased HIV incidence. This endpoint was assessed in a cohort of >48,000 randomly selected adults in the study communities. We evaluated the impact of UTT on HIV drug resistance in this cohort and compared other resistance-related outcomes in participants with recent versus non-recent HIV infection.