Publication

The effects of participation in an intensive HIV prevention trial on long term socio-demographic outcomes among young women in rural South Africa

Citation

Stoner MCD, Browne EN, Kabudula C, Rosenberg M, Gomez-Olive FX, Neilands TB, Kang Dufour MS, Ahern J, Kahn K, Lippman SA, Pettifor AE. The effects of participation in an intensive HIV prevention trial on long term socio-demographic outcomes among young women in rural South Africa. J Acquir Immune Defic Syndr. 2023 PMC10079564

Abstract

Background: Research trial participation may influence health outcomes regardless of the intervention assigned but is often not assessed. Setting: We investigated how participation in an HIV prevention trial (the HIV Prevention Trials Network (HPTN) 068 study) affected health outcomes four years after the study in adolescent girls and young women (AGYW) in South Africa beyond effects of the tested intervention. Methods: We developed an analytical cohort that included the HPTN 068 trial participants from the Agincourt Health and Demographic Surveillance System (AHDSS) and resembled HPTN 068 trial enrollees (aged 13 to 20 years and in grades 8-11 in 2011) using inverse probability of treatment weights. We estimated risk differences (RD) for the association between trial participation and education and early parity (age