Our Mission

The HPTN is dedicated to the discovery and development of new and innovative research strategies to reduce the acquisition and transmission of HIV.


The HIV Prevention Trials Network (HPTN) is a worldwide collaborative clinical trials network that brings together investigators, ethicists, community and other partners to develop and test the safety and efficacy of interventions designed to prevent the acquisition and transmission of HIV. HPTN studies evaluate new HIV prevention interventions and strategies in populations and geographical regions that bear a disproportionate burden of infection. The HPTN is committed to the highest ethical standards for its clinical trials and recognizes the importance of community engagement in all phases of the research process.

The HPTN research agenda is focused primarily on the use of integrated strategies: use of antiretroviral drugs (antiretroviral therapy and pre-exposure prophylaxis), interventions for substance abuse, particularly injection drug use, and behavioral risk reduction interventions with structural interventions.

The HPTN was established in 2000, building on the work of the HIV Network for Prevention Trials (HIVNET). HPTN’s Leadership and Operations Center (LOC), is based at FHI 360, Durham, North Carolina. The Laboratory Center (LC) is at Johns Hopkins University, Baltimore, Maryland and the Statistical and Data Management Center (SDMC) is housed within the Statistical Center for HIV/AIDS Research and Prevention (SCHARP) at the Fred Hutchinson Cancer Research Center in Seattle, Washington. The HPTN Modelling Centre, part of the SDMC, is a collaboration between the Department of Infectious Diseases Epidemiology at Imperial College London and SCHARP.

HPTN receives funding from three NIH institutes: the National Institute of Allergy and Infectious Diseases, the National Institute of Mental Health and the National Institute on Drug Abuse.


Learn More

HPTN Populations of Focus

HPTN Fact Sheet

The HPTN Leadership and Operations Center (LOC) – webinar

The HPTN Statistical and Data Management Center (SDMC) – webinar

Conversations with the HPTN

Dr. Zubair Lukyamuzi, protocol chair for HPTN 111, is a public health specialist and researcher at the Makerere University-Johns Hopkins University (MU-JHU) research collaboration in Kampala, Uganda. He has served as a principal investigator on various studies, including a Fogarty/NIH-funded experimental study that assessed the role of community health workers (CHW) in supporting disclosure among adults living with HIV in heterosexual relationships in rural Uganda.

Jason L. Brock, a member of the HPTN 096 study, is a peer supporter guiding Black gay, bisexual, same-gender loving, and other men who have sex with men in Dallas. His background includes education, grant management, program development, and advocacy. Jason's goal is for others to become better educated and help people overcome the stigma of receiving proper care and treatment. He holds a bachelor's degree in business management with coursework in applied science in education.

Josias da Silva Freitas is a community educator and liaison for the Black community at the Instituto de Pesquisa Clinica Evandro Chagas (IPEC) CRS in Rio de Janeiro, Brazil. He has worked at IPEC CRS since the early 1990s as part of the community education team recruiting and engaging populations deemed most vulnerable, especially the Black community, accessing, welcoming, and promoting HIV prevention and linkage to care. Josias also contributes to the development of strategies to support HIV prevention. 

Dr. Sunil Suhas Solomon, a member of the HPTN Substance Use Scientific Committee and HPTN 103 protocol team, is a professor of medicine and epidemiology at the Johns Hopkins University School of Medicine in Baltimore, Md. His research primarily focuses on preventing and treating HIV, viral hepatitis, and other infectious diseases among vulnerable populations such as people who inject drugs.