The HIV Prevention Trials Network (HPTN) has launched two new phase 2 studies, HPTN 076 and HPTN 077, which are designed to evaluate new drugs to protect people from getting infected with HIV.
HPTN 076 and HPTN 077 are among the first studies to test long-acting, injectable antiretroviral drugs in persons without HIV infection. Antiretroviral drugs are commonly used now as treatment in individuals with HIV infection.
The studies are funded by the National Institute of Allergy and Infectious Diseases, which is part of the U.S. National Institutes of Health.
Study results presented today at the Conference on Retroviruses and Opportunistic Infections by the HIV Prevention Trials Network (HPTN) and the National Institutes of Health (NIH) show that a series of community efforts can increase the number of people who get tested and know their HIV status, especially among men and young people with HIV who might otherwise transmit the virus to others. The study was also able to demonstrate a modest 14% reduction in new HIV infections in the intervention communities compared to the control communities.
When the HIV Prevention Trials Network (HPTN) 052 investigators released their landmark study results last year showing that treatment can reduce HIV transmission by 96% in serodiscordant couples, questions were raised about the cost of early antiretroviral therapy (ART) and if it should be universally implemented. Data presented today at the XIX International AIDS Conference in Washington, D.C. show that treatment as prevention is “very cost-effective”.
Study results released today by the HIV Prevention Trials Network (HPTN) show additional benefits of early antiretroviral therapy (ART) in HIV clinical outcomes. Expanded analysis of HPTN 052 study data, presented today at the XIX International AIDS Conference in Washington, D.C., demonstrated that early versus delayed ART showed a trend toward delaying the time to both AIDS and non-AIDS primary events and significantly delayed the time to AIDS events, death and tuberculosis. The overall incidence of clinical events was significantly lower in participants treated in the early therapy arm.
Study results released today by the HIV Prevention Trials Network (HPTN) show disturbing rates of new HIV infections occurring among black gay and bisexual men in the U.S. (also known as men who have sex with men, or MSM), particularly young black MSM. The HPTN 061 study showed that the overall rate of new HIV infection among black MSM in this study was 2.8% per year, a rate that is nearly 50% higher than in white MSM in the U.S.
March 8, 2012 - Study results released today indicate that the HIV incidence rate for US women living in areas hardest hit by the epidemic is much higher than the overall estimated incidence rate in the US for black adolescent and adult women. The HIV Prevention Trials Network (HPTN) announced results from its HPTN 064 Women’s HIV Seroincidence Study (ISIS) which found an HIV incidence of 0.24% in the study cohort of 2,099 women (88% black), a rate that is five fold higher than that estimated for black women overall by the Centers for Disease Control and Prevention (CDC).