HPTN at CROI 2020

 

CROI

 

HPTN researchers virtually presented 14 abstracts showcasing HPTN 052, HPTN 071, HPTN 075, HPTN 078, and the HPTN Modelling Centre and HPTN Laboratory Center's ongoing work at the 27th annual Conference on Retroviruses and Opportunistic Infections (CROI).

 

052
Sexually Transmitted Infections Among HIV Serodiscordant Sexual Partners: HPTN 052

 

HPTN 052 was a Phase III, two-arm, randomized, controlled, multi-center trial that determined antiretroviral therapy (ART) can prevent the sexual transmission of HIV-1 in HIV-1 serodiscordant couples.

 

 

 

  • 052
    Use of Phylogenetic Analysis to Infer the Direction of HIV Transmission
    HPTN Laboratory Center’s Dr. Yinfeng Zhang presented Use of Phylogenetic Analysis to Infer the Direction of HIV Transmission. The poster showed accurate predictions of transmission direction were obtained using whole-genome and pol next-generation sequencing data. Further research is needed to evaluate the performance of these methods in other settings and cohorts and in cases where both individuals (source and recipient) have a long-term infection.

 

 

 

HPTN 071 (PopART) examined the impact of a package of HIV prevention interventions on community-level HIV incidence. Results showed delivery of an HIV prevention strategy that includes offering in-home HIV testing to everyone, with immediate referral to HIV care, and treatment for people living with HIV based on prevailing in-country guidelines, can substantially reduce new HIV infections.

  • In a third study-related poster from the HPTN Laboratory Center, Evaluation of Cross-Sectional HIV Incidence Testing In the HPTN 071 (PopART) Trial, Ethan Klock showed that a widely-used cross-sectional incidence algorithm that included the limiting antigen avidity assay and HIV viral load yielded accurate point estimates of incidence, despite high rates of viral suppression among those with both prevalent and incident infection.

 

075
HIV Superinfection Among MSM and TGW in Sub-Saharan Africa: HPTN 075

HPTN 075 evaluated the feasibility of HIV prevention research among men who have sex with men (MSM) and transgender women (TGW) in three countries in sub-Saharan Africa. Findings showed participants were at an alarming risk for getting HIV.

  • HPTN Laboratory Center’s Philip Palumbo presented HIV Superinfection Among MSM and TGW in Sub-Saharan Africa: HPTN 075. The poster demonstrated the incidence of HIV superinfection among seroconverters was significantly higher than the rate of primary HIV infection. This finding contrasts with previous studies reporting superinfection rates were equal to or lower than the rate of primary HIV infection.

 

 

 

 

HPTN 078 was a U.S.-based research study designed to evaluate the effectiveness of a combined HIV prevention strategy, including a peer-to-peer referral method to recruit men who have sex with men (MSM) living with unsuppressed HIV and an intervention to help them achieve and maintain viral suppression.

Two other posters from the HPTN Laboratory Center presented additional findings from this study.

 

Modelling
Using Surveillance Data to Measure Trial HIV Incidence Outcomes: A Modelling Study

HPTN Modelling Centre

 

 

 

Additional posters from the HPTN Laboratory Center

  • Lab
    Indeterminate HIV Rapid Test Results: Outcomes and Risk Factors
    George Mwinnyaa’s poster Indeterminate HIV Rapid Test Results: Outcomes and Risk Factors suggests HIV surveillance programs should develop a protocol for reporting individuals with mixed or persistently indeterminate HIV results in multiple follow-up visits.